Project ENTHUSE was launched in 2008 with £27 million from the Wellcome Trust, the Department for Education (formerly Department for Children, Schools and Families), AstraZeneca, AstraZeneca Science Teaching Trust (renamed Primary Science Teaching Trust in 2013), BAE Systems, BP, General Electric Foundation, GlaxoSmithKline, Rolls-Royce, Vodafone and Vodafone Group Foundation.

In 2013/14 Project ENTHUSE received further funding of over £22 million from the Department for Education, the Wellcome Trust, BAE Systems, BPRolls-RoyceRoyal Society of Chemistry, Institution of Engineering and Technology  and the Institution of Mechanical Engineers.

These unique group of organisations have come together to bring about inspired science teaching through the continuing professional development of teachers of science and technicians across the UK, primarily by providing ENTHUSE Awards to help fund participation in continuing professional development courses delivered by the National Science Learning Centre. Through this support, pupils are more inspired by and engaged in their science education.